Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone G from the Caribbean Sponge Plakortis sp.
Identifieur interne : 002271 ( Main/Exploration ); précédent : 002270; suivant : 002272Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone G from the Caribbean Sponge Plakortis sp.
Auteurs : Deborah J. Gochfeld [États-Unis] ; Mark T. Hamann [États-Unis]Source :
- Journal of Natural Products [ 0163-3864 ] ; 2001.
Abstract
The bioassay- and spectroscopic-guided fractionation of the antimalarial extract from a Jamaican sponge, Plakortis sp., resulted in the isolation of three metabolites. The previously reported bromoaromatic filiformin (1) was obtained from our sample of Plakortis sp., and the potential origins of this compound are discussed. The peroxide-containing metabolite, plakortide F (2), is a more typical Plakortis metabolite and was shown to exhibit significant activity against Plasmodium falciparum in vitro. The isolation, structure, and bioactivity of a new lactone, plakortone G (3), are also reported.
Url:
DOI: 10.1021/np010216u
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000C40
- to stream Istex, to step Curation: 000C40
- to stream Istex, to step Checkpoint: 001094
- to stream Main, to step Merge: 002295
- to stream Main, to step Curation: 002271
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone G from the Caribbean Sponge Plakortis sp.</title><author><name sortKey="Gochfeld, Deborah J" sort="Gochfeld, Deborah J" uniqKey="Gochfeld D" first="Deborah J." last="Gochfeld">Deborah J. Gochfeld</name></author><author><name sortKey="Hamann, Mark T" sort="Hamann, Mark T" uniqKey="Hamann M" first="Mark T." last="Hamann">Mark T. Hamann</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E389ADD20E0C4E596E7D3F4FCF65B36453731B2A</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1021/np010216u</idno><idno type="url">https://api.istex.fr/ark:/67375/TPS-WQT368LR-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000C40</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000C40</idno><idno type="wicri:Area/Istex/Curation">000C40</idno><idno type="wicri:Area/Istex/Checkpoint">001094</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001094</idno><idno type="wicri:doubleKey">0163-3864:2001:Gochfeld D:isolation:and:biological</idno><idno type="wicri:Area/Main/Merge">002295</idno><idno type="wicri:Area/Main/Curation">002271</idno><idno type="wicri:Area/Main/Exploration">002271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone
G from the Caribbean Sponge <hi rend="italic">Plakortis</hi> sp.</title><author><name sortKey="Gochfeld, Deborah J" sort="Gochfeld, Deborah J" uniqKey="Gochfeld D" first="Deborah J." last="Gochfeld">Deborah J. Gochfeld</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pharmacognosy and National Center for Natural Products Research, University of Mississippi,University</wicri:cityArea></affiliation></author><author><name sortKey="Hamann, Mark T" sort="Hamann, Mark T" uniqKey="Hamann M" first="Mark T." last="Hamann">Mark T. Hamann</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>Department of Pharmacognosy and National Center for Natural Products Research, University of Mississippi,University</wicri:cityArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Natural Products</title><title level="j" type="abbrev">J. Nat. Prod.</title><idno type="ISSN">0163-3864</idno><idno type="eISSN">1520-6025</idno><imprint><publisher>American Chemical Society</publisher><date type="e-published" when="2001-10-23">2001</date><date when="2001-11-26">2001</date><biblScope unit="vol">64</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1477">1477</biblScope><biblScope unit="page" to="1479">1479</biblScope></imprint><idno type="ISSN">0163-3864</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0163-3864</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The bioassay- and spectroscopic-guided fractionation of the antimalarial extract from a Jamaican sponge, Plakortis sp., resulted in the isolation of three metabolites. The previously reported bromoaromatic filiformin (1) was obtained from our sample of Plakortis sp., and the potential origins of this compound are discussed. The peroxide-containing metabolite, plakortide F (2), is a more typical Plakortis metabolite and was shown to exhibit significant activity against Plasmodium falciparum in vitro. The isolation, structure, and bioactivity of a new lactone, plakortone G (3), are also reported.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État du Mississippi</li></region></list><tree><country name="États-Unis"><region name="État du Mississippi"><name sortKey="Gochfeld, Deborah J" sort="Gochfeld, Deborah J" uniqKey="Gochfeld D" first="Deborah J." last="Gochfeld">Deborah J. Gochfeld</name></region><name sortKey="Hamann, Mark T" sort="Hamann, Mark T" uniqKey="Hamann M" first="Mark T." last="Hamann">Mark T. Hamann</name><name sortKey="Hamann, Mark T" sort="Hamann, Mark T" uniqKey="Hamann M" first="Mark T." last="Hamann">Mark T. Hamann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002271 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002271 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E389ADD20E0C4E596E7D3F4FCF65B36453731B2A
|texte= Isolation and Biological Evaluation of Filiformin, Plakortide F, and Plakortone G from the Caribbean Sponge Plakortis sp.
}}
| This area was generated with Dilib version V0.6.33. |  |